Metallothionein 3 Controls the Phenotype and Metabolic Programming of Alternatively Activated Macrophages
Identifieur interne : 000638 ( Main/Exploration ); précédent : 000637; suivant : 000639Metallothionein 3 Controls the Phenotype and Metabolic Programming of Alternatively Activated Macrophages
Auteurs : Debabrata Chowdhury [États-Unis] ; Hani Alrefai [États-Unis] ; Julio A. Landero Figueroa [États-Unis] ; Kathleen Candor [États-Unis] ; Aleksey Porollo [États-Unis] ; Roger Fecher [États-Unis] ; Senad Divanovic [États-Unis] ; George S. Deepe [États-Unis] ; Kavitha Subramanian Vignesh [États-Unis]Source :
- Cell reports [ 2211-1247 ] ; 2019.
Abstract
Alternatively activated (M2) macrophages promote wound healing but weaken antimicrobial defenses. The mechanisms that enforce macrophage divergence and dictate the phenotypic and metabolic characteristics of M2 macrophages remain elusive. We show that alternative activation with interleukin (IL)-4 induces expression of metallothionein 3 (MT3) that regulates macrophage polarization and function. MT3 was requisite for metabolic reprograming in IL-4-stimulated macrophages or M(IL-4) macrophages to promote mitochondrial respiration and suppress glycolysis. MT3 fostered an M(IL-4) phenotype, suppressed hypoxia inducible factor (HIF)1α activation, and thwarted the emergence of a proinflammatory M1 program in macrophages. MT3 deficiency augmented macrophage plasticity, resulting in enhanced interferon γ (IFNγ) responsiveness and a dampened M(IL-4) phenotype. Thus, MT3 programs the phenotype and metabolic fate of M(IL-4) macrophages.
Url:
DOI: 10.1016/j.celrep.2019.05.093
PubMed: 31242420
PubMed Central: 6664296
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000384
- to stream Pmc, to step Curation: 000384
- to stream Pmc, to step Checkpoint: 000588
- to stream Ncbi, to step Merge: 000729
- to stream Ncbi, to step Curation: 000729
- to stream Ncbi, to step Checkpoint: 000729
- to stream Main, to step Merge: 000638
- to stream Main, to step Curation: 000638
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Metallothionein 3 Controls the Phenotype and Metabolic Programming of Alternatively Activated Macrophages</title><author><name sortKey="Chowdhury, Debabrata" sort="Chowdhury, Debabrata" uniqKey="Chowdhury D" first="Debabrata" last="Chowdhury">Debabrata Chowdhury</name><affiliation wicri:level="1"><nlm:aff id="A1">Division of Infectious Diseases, College of Medicine, University of Cincinnati, Cincinnati, OH 45267, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Infectious Diseases, College of Medicine, University of Cincinnati, Cincinnati, OH 45267</wicri:regionArea><wicri:noRegion>OH 45267</wicri:noRegion></affiliation><affiliation><nlm:aff id="A7">These authors contributed equally</nlm:aff></affiliation></author><author><name sortKey="Alrefai, Hani" sort="Alrefai, Hani" uniqKey="Alrefai H" first="Hani" last="Alrefai">Hani Alrefai</name><affiliation wicri:level="1"><nlm:aff id="A1">Division of Infectious Diseases, College of Medicine, University of Cincinnati, Cincinnati, OH 45267, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Infectious Diseases, College of Medicine, University of Cincinnati, Cincinnati, OH 45267</wicri:regionArea><wicri:noRegion>OH 45267</wicri:noRegion></affiliation><affiliation><nlm:aff id="A7">These authors contributed equally</nlm:aff></affiliation></author><author><name sortKey="Figueroa, Julio A Landero" sort="Figueroa, Julio A Landero" uniqKey="Figueroa J" first="Julio A. Landero" last="Figueroa">Julio A. Landero Figueroa</name><affiliation wicri:level="1"><nlm:aff id="A2">University of Cincinnati/Agilent Technologies Metallomics Center of the Americas, Department of Chemistry, University of Cincinnati, Cincinnati, OH 45221, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Cincinnati/Agilent Technologies Metallomics Center of the Americas, Department of Chemistry, University of Cincinnati, Cincinnati, OH 45221</wicri:regionArea><wicri:noRegion>OH 45221</wicri:noRegion></affiliation></author><author><name sortKey="Candor, Kathleen" sort="Candor, Kathleen" uniqKey="Candor K" first="Kathleen" last="Candor">Kathleen Candor</name><affiliation wicri:level="1"><nlm:aff id="A2">University of Cincinnati/Agilent Technologies Metallomics Center of the Americas, Department of Chemistry, University of Cincinnati, Cincinnati, OH 45221, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Cincinnati/Agilent Technologies Metallomics Center of the Americas, Department of Chemistry, University of Cincinnati, Cincinnati, OH 45221</wicri:regionArea><wicri:noRegion>OH 45221</wicri:noRegion></affiliation></author><author><name sortKey="Porollo, Aleksey" sort="Porollo, Aleksey" uniqKey="Porollo A" first="Aleksey" last="Porollo">Aleksey Porollo</name><affiliation wicri:level="1"><nlm:aff id="A3">Center for Autoimmune Genomics and Etiology and Division of Biomedical Informatics, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Autoimmune Genomics and Etiology and Division of Biomedical Informatics, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229</wicri:regionArea><wicri:noRegion>OH 45229</wicri:noRegion></affiliation></author><author><name sortKey="Fecher, Roger" sort="Fecher, Roger" uniqKey="Fecher R" first="Roger" last="Fecher">Roger Fecher</name><affiliation wicri:level="1"><nlm:aff id="A4">Department of Pathology, Albert Einstein College of Medicine, Montefiore Medical Center, New York, NY 10467, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, Albert Einstein College of Medicine, Montefiore Medical Center, New York, NY 10467</wicri:regionArea><wicri:noRegion>NY 10467</wicri:noRegion></affiliation></author><author><name sortKey="Divanovic, Senad" sort="Divanovic, Senad" uniqKey="Divanovic S" first="Senad" last="Divanovic">Senad Divanovic</name><affiliation wicri:level="1"><nlm:aff id="A5">Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45220, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45220</wicri:regionArea><wicri:noRegion>OH 45220</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A6">Division of Immunobiology and Center for Inflammation and Tolerance, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Immunobiology and Center for Inflammation and Tolerance, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229</wicri:regionArea><wicri:noRegion>OH 45229</wicri:noRegion></affiliation></author><author><name sortKey="Deepe, George S" sort="Deepe, George S" uniqKey="Deepe G" first="George S." last="Deepe">George S. Deepe</name><affiliation wicri:level="1"><nlm:aff id="A1">Division of Infectious Diseases, College of Medicine, University of Cincinnati, Cincinnati, OH 45267, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Infectious Diseases, College of Medicine, University of Cincinnati, Cincinnati, OH 45267</wicri:regionArea><wicri:noRegion>OH 45267</wicri:noRegion></affiliation></author><author><name sortKey="Vignesh, Kavitha Subramanian" sort="Vignesh, Kavitha Subramanian" uniqKey="Vignesh K" first="Kavitha Subramanian" last="Vignesh">Kavitha Subramanian Vignesh</name><affiliation wicri:level="1"><nlm:aff id="A1">Division of Infectious Diseases, College of Medicine, University of Cincinnati, Cincinnati, OH 45267, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Infectious Diseases, College of Medicine, University of Cincinnati, Cincinnati, OH 45267</wicri:regionArea><wicri:noRegion>OH 45267</wicri:noRegion></affiliation><affiliation><nlm:aff id="A8">Lead Contact</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">31242420</idno><idno type="pmc">6664296</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6664296</idno><idno type="RBID">PMC:6664296</idno><idno type="doi">10.1016/j.celrep.2019.05.093</idno><date when="2019">2019</date><idno type="wicri:Area/Pmc/Corpus">000384</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000384</idno><idno type="wicri:Area/Pmc/Curation">000384</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000384</idno><idno type="wicri:Area/Pmc/Checkpoint">000588</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000588</idno><idno type="wicri:Area/Ncbi/Merge">000729</idno><idno type="wicri:Area/Ncbi/Curation">000729</idno><idno type="wicri:Area/Ncbi/Checkpoint">000729</idno><idno type="wicri:Area/Main/Merge">000638</idno><idno type="wicri:Area/Main/Curation">000638</idno><idno type="wicri:Area/Main/Exploration">000638</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Metallothionein 3 Controls the Phenotype and Metabolic Programming of Alternatively Activated Macrophages</title><author><name sortKey="Chowdhury, Debabrata" sort="Chowdhury, Debabrata" uniqKey="Chowdhury D" first="Debabrata" last="Chowdhury">Debabrata Chowdhury</name><affiliation wicri:level="1"><nlm:aff id="A1">Division of Infectious Diseases, College of Medicine, University of Cincinnati, Cincinnati, OH 45267, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Infectious Diseases, College of Medicine, University of Cincinnati, Cincinnati, OH 45267</wicri:regionArea><wicri:noRegion>OH 45267</wicri:noRegion></affiliation><affiliation><nlm:aff id="A7">These authors contributed equally</nlm:aff></affiliation></author><author><name sortKey="Alrefai, Hani" sort="Alrefai, Hani" uniqKey="Alrefai H" first="Hani" last="Alrefai">Hani Alrefai</name><affiliation wicri:level="1"><nlm:aff id="A1">Division of Infectious Diseases, College of Medicine, University of Cincinnati, Cincinnati, OH 45267, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Infectious Diseases, College of Medicine, University of Cincinnati, Cincinnati, OH 45267</wicri:regionArea><wicri:noRegion>OH 45267</wicri:noRegion></affiliation><affiliation><nlm:aff id="A7">These authors contributed equally</nlm:aff></affiliation></author><author><name sortKey="Figueroa, Julio A Landero" sort="Figueroa, Julio A Landero" uniqKey="Figueroa J" first="Julio A. Landero" last="Figueroa">Julio A. Landero Figueroa</name><affiliation wicri:level="1"><nlm:aff id="A2">University of Cincinnati/Agilent Technologies Metallomics Center of the Americas, Department of Chemistry, University of Cincinnati, Cincinnati, OH 45221, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Cincinnati/Agilent Technologies Metallomics Center of the Americas, Department of Chemistry, University of Cincinnati, Cincinnati, OH 45221</wicri:regionArea><wicri:noRegion>OH 45221</wicri:noRegion></affiliation></author><author><name sortKey="Candor, Kathleen" sort="Candor, Kathleen" uniqKey="Candor K" first="Kathleen" last="Candor">Kathleen Candor</name><affiliation wicri:level="1"><nlm:aff id="A2">University of Cincinnati/Agilent Technologies Metallomics Center of the Americas, Department of Chemistry, University of Cincinnati, Cincinnati, OH 45221, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Cincinnati/Agilent Technologies Metallomics Center of the Americas, Department of Chemistry, University of Cincinnati, Cincinnati, OH 45221</wicri:regionArea><wicri:noRegion>OH 45221</wicri:noRegion></affiliation></author><author><name sortKey="Porollo, Aleksey" sort="Porollo, Aleksey" uniqKey="Porollo A" first="Aleksey" last="Porollo">Aleksey Porollo</name><affiliation wicri:level="1"><nlm:aff id="A3">Center for Autoimmune Genomics and Etiology and Division of Biomedical Informatics, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Autoimmune Genomics and Etiology and Division of Biomedical Informatics, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229</wicri:regionArea><wicri:noRegion>OH 45229</wicri:noRegion></affiliation></author><author><name sortKey="Fecher, Roger" sort="Fecher, Roger" uniqKey="Fecher R" first="Roger" last="Fecher">Roger Fecher</name><affiliation wicri:level="1"><nlm:aff id="A4">Department of Pathology, Albert Einstein College of Medicine, Montefiore Medical Center, New York, NY 10467, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, Albert Einstein College of Medicine, Montefiore Medical Center, New York, NY 10467</wicri:regionArea><wicri:noRegion>NY 10467</wicri:noRegion></affiliation></author><author><name sortKey="Divanovic, Senad" sort="Divanovic, Senad" uniqKey="Divanovic S" first="Senad" last="Divanovic">Senad Divanovic</name><affiliation wicri:level="1"><nlm:aff id="A5">Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45220, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45220</wicri:regionArea><wicri:noRegion>OH 45220</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A6">Division of Immunobiology and Center for Inflammation and Tolerance, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Immunobiology and Center for Inflammation and Tolerance, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229</wicri:regionArea><wicri:noRegion>OH 45229</wicri:noRegion></affiliation></author><author><name sortKey="Deepe, George S" sort="Deepe, George S" uniqKey="Deepe G" first="George S." last="Deepe">George S. Deepe</name><affiliation wicri:level="1"><nlm:aff id="A1">Division of Infectious Diseases, College of Medicine, University of Cincinnati, Cincinnati, OH 45267, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Infectious Diseases, College of Medicine, University of Cincinnati, Cincinnati, OH 45267</wicri:regionArea><wicri:noRegion>OH 45267</wicri:noRegion></affiliation></author><author><name sortKey="Vignesh, Kavitha Subramanian" sort="Vignesh, Kavitha Subramanian" uniqKey="Vignesh K" first="Kavitha Subramanian" last="Vignesh">Kavitha Subramanian Vignesh</name><affiliation wicri:level="1"><nlm:aff id="A1">Division of Infectious Diseases, College of Medicine, University of Cincinnati, Cincinnati, OH 45267, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Infectious Diseases, College of Medicine, University of Cincinnati, Cincinnati, OH 45267</wicri:regionArea><wicri:noRegion>OH 45267</wicri:noRegion></affiliation><affiliation><nlm:aff id="A8">Lead Contact</nlm:aff></affiliation></author></analytic><series><title level="j">Cell reports</title><idno type="eISSN">2211-1247</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>SUMMARY</title><p id="P3">Alternatively activated (M2) macrophages promote wound healing but weaken antimicrobial defenses. The mechanisms that enforce macrophage divergence and dictate the phenotypic and metabolic characteristics of M2 macrophages remain elusive. We show that alternative activation with interleukin (IL)-4 induces expression of metallothionein 3 (MT3) that regulates macrophage polarization and function. MT3 was requisite for metabolic reprograming in IL-4-stimulated macrophages or M(IL-4) macrophages to promote mitochondrial respiration and suppress glycolysis. MT3 fostered an M(IL-4) phenotype, suppressed hypoxia inducible factor (HIF)1α activation, and thwarted the emergence of a proinflammatory M1 program in macrophages. MT3 deficiency augmented macrophage plasticity, resulting in enhanced interferon γ (IFNγ) responsiveness and a dampened M(IL-4) phenotype. Thus, MT3 programs the phenotype and metabolic fate of M(IL-4) macrophages.</p></div></front></TEI><affiliations><list><country><li>États-Unis</li></country></list><tree><country name="États-Unis"><noRegion><name sortKey="Chowdhury, Debabrata" sort="Chowdhury, Debabrata" uniqKey="Chowdhury D" first="Debabrata" last="Chowdhury">Debabrata Chowdhury</name></noRegion><name sortKey="Alrefai, Hani" sort="Alrefai, Hani" uniqKey="Alrefai H" first="Hani" last="Alrefai">Hani Alrefai</name><name sortKey="Candor, Kathleen" sort="Candor, Kathleen" uniqKey="Candor K" first="Kathleen" last="Candor">Kathleen Candor</name><name sortKey="Deepe, George S" sort="Deepe, George S" uniqKey="Deepe G" first="George S." last="Deepe">George S. Deepe</name><name sortKey="Divanovic, Senad" sort="Divanovic, Senad" uniqKey="Divanovic S" first="Senad" last="Divanovic">Senad Divanovic</name><name sortKey="Divanovic, Senad" sort="Divanovic, Senad" uniqKey="Divanovic S" first="Senad" last="Divanovic">Senad Divanovic</name><name sortKey="Fecher, Roger" sort="Fecher, Roger" uniqKey="Fecher R" first="Roger" last="Fecher">Roger Fecher</name><name sortKey="Figueroa, Julio A Landero" sort="Figueroa, Julio A Landero" uniqKey="Figueroa J" first="Julio A. Landero" last="Figueroa">Julio A. Landero Figueroa</name><name sortKey="Porollo, Aleksey" sort="Porollo, Aleksey" uniqKey="Porollo A" first="Aleksey" last="Porollo">Aleksey Porollo</name><name sortKey="Vignesh, Kavitha Subramanian" sort="Vignesh, Kavitha Subramanian" uniqKey="Vignesh K" first="Kavitha Subramanian" last="Vignesh">Kavitha Subramanian Vignesh</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/ChloroquineV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000638 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000638 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= ChloroquineV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:6664296
|texte= Metallothionein 3 Controls the Phenotype and Metabolic Programming of Alternatively Activated Macrophages
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:31242420" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a ChloroquineV1
| This area was generated with Dilib version V0.6.33. |  |